A novel class of sodium/calcium exchanger inhibitor: design, synthesis, and structure–activity relationships of 3, 4-dihydro-2 (1H)-quinazolinone derivatives

H Hasegawa, M Muraoka, M Ohmori, K Matsui…

文献索引：Hasegawa, Hirohiko; Muraoka, Masami; Ohmori, Mikiko; Matsui, Kazuki; Kojima, Atsuyuki Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3721 - 3735

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被引用次数: 13

摘要

Design, synthesis, and structure–activity relationships of 3, 4-dihydro-2 (1H)-quinazolinone derivatives as inhibitors of the sodium/calcium (Na+/Ca2+) exchanger are discussed. These studies, based on a lead compound 9a, which was identified in our library, involved systematic modification of three regions and revealed that (1) the 3, 4-dihydro-2 (1H)- quinazolinone having a tertiary amino alkyl side chain at the 3-position is essential for ...