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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Structure-activity relationships of antimalarial indolo [3, 2-c] quinolines [1, 2]

LM Werbel, SJ Kesten, WR Turner

文献索引：Werbel, L. M.; Kesten, S. J.; Turner, W. R. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852

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被引用次数: 24

摘要

Abstract Structure-activity relationships have been ascertained and chemical methodology developed for a series of antimalarial 3-chloroindolo [3, 2-c] quinoline-5-oxides. The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3. Substitution at positions 7, 8, 9, 10 is not essential, although the most potent analog in our studies was the 8-nitro compound 4vv.

Methyl N-(4-methoxyphenyl)-beta-alaninate结构式

Methyl N-(4-met...

~%

6-甲氧基-2,3-二氢喹啉-4-酮结构式

6-甲氧基-2,3-二氢喹啉-4-酮

methyl N-tosyl-3-(4-methoxyanilino)propionate结构式

methyl N-tosyl-...

~%

6-甲氧基-2,3-二氢喹啉-4-酮结构式

6-甲氧基-2,3-二氢喹啉-4-酮

methyl N-(3-chlorophenyl)-β-alaninate结构式

methyl N-(3-chl...

~%

11H-Indolo[3,2-c]quinolin-9-amine, 3-chloro-N,N-diethyl-8-methoxy-结构式

11H-Indolo[3,2-...

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

~%

11H-Indolo[3,2-c]quinolin-9-amine, 3-chloro-N,N-diethyl-8-methoxy-结构式

11H-Indolo[3,2-...

间氯苯胺结构式

~%

11H-Indolo[3,2-c]quinolin-9-amine, 3-chloro-N,N-diethyl-8-methoxy-结构式

11H-Indolo[3,2-...

4(1H)-Quinolinone,7-chloro-2,3-dihydro-1-[(4-methylphenyl)sulfonyl]-结构式

4(1H)-Quinolino...

~%

11H-Indolo[3,2-c]quinolin-9-amine, 3-chloro-N,N-diethyl-8-methoxy-结构式

11H-Indolo[3,2-...

3-(苯基氨基)丙酸甲酯结构式

3-(苯基氨基)丙酸甲酯

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

2,3-二氢-1-[(4-甲基苯基)磺酰基]-4(1H)-喹啉酮结构式

2,3-二氢-1-[(4-甲基...

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

methyl 3-[(4-methylphenyl)sulfonyl-phenyl-amino]propanoate结构式

methyl 3-[(4-me...

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

b-Alanine,N-[(4-methylphenyl)sulfonyl]-N-phenyl-结构式

b-Alanine,N-[(4...

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

2,3-二氢-1H-喹啉-4-酮结构式

2,3-二氢-1H-喹啉-4-酮

盐酸苯肼结构式

~%

11H-indolo[3,2-c]quinoline结构式

11H-indolo[3,2-...

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

~%

7-氯-2,3-二氢喹啉-4(1H)-酮结构式

7-氯-2,3-二氢喹啉-4(1H)-酮

methyl N-(3-chlorophenyl)-β-alaninate结构式

methyl N-(3-chl...

~%

7-氯-2,3-二氢喹啉-4(1H)-酮结构式

7-氯-2,3-二氢喹啉-4(1H)-酮

间氯苯胺结构式

~%

7-氯-2,3-二氢喹啉-4(1H)-酮结构式

7-氯-2,3-二氢喹啉-4(1H)-酮

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

~%

7-氯-2,3-二氢喹啉-4(1H)-酮结构式

7-氯-2,3-二氢喹啉-4(1H)-酮

5-氯-2,3-二氢喹啉-4(1H)-酮结构式

5-氯-2,3-二氢喹啉-4(1H)-酮

1-(1-(4-chloro-2-nitrophenyl)ethylidene)-2-phenylhydrazine结构式

1-(1-(4-chloro-...

~33%

2-(4-chloro-2-nitrophenyl)-1H-indole结构式

2-(4-chloro-2-n...

2-硝基苯乙酮结构式

2-硝基苯乙酮

~%

2-(2-nitrophenyl)-1H-indole结构式

2-(2-nitropheny...

methyl N-(3-chlorophenyl)-β-alaninate结构式

methyl N-(3-chl...

~%

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

间氯苯胺结构式

~%

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

4-甲基疏基苯胺盐酸盐结构式

4-甲基疏基苯胺盐酸盐

~%

(4-(METHYLTHIO)PHENYL)HYDRAZINE结构式

(4-(METHYLTHIO)...

6-甲氧基-2,3-二氢喹啉-4-酮结构式

6-甲氧基-2,3-二氢喹啉-4-酮

盐酸苯肼结构式

~28%

2-methoxy-11H-indolo[3,2-c]quinoline结构式

2-methoxy-11H-i...

Methyl N-(4-methoxyphenyl)-beta-alaninate结构式

Methyl N-(4-met...

~%

2-methoxy-11H-indolo[3,2-c]quinoline结构式

2-methoxy-11H-i...

6-methoxy-1-tosyl-2,3-dihydroquinolin-4(1H)-one结构式

6-methoxy-1-tos...

~%

2-methoxy-11H-indolo[3,2-c]quinoline结构式

2-methoxy-11H-i...

methyl N-tosyl-3-(4-methoxyanilino)propionate结构式

methyl N-tosyl-...

~%

2-methoxy-11H-indolo[3,2-c]quinoline结构式

2-methoxy-11H-i...

对甲氧基苯胺结构式

对甲氧基苯胺

~%

2-methoxy-11H-indolo[3,2-c]quinoline结构式

2-methoxy-11H-i...

3-(苯基氨基)丙酸甲酯结构式

3-(苯基氨基)丙酸甲酯

~%

b-Alanine,N-[(4-methylphenyl)sulfonyl]-N-phenyl-结构式

b-Alanine,N-[(4...

methyl N-(3-chlorophenyl)-β-alaninate结构式

methyl N-(3-chl...

~%

4(1H)-Quinolinone,7-chloro-2,3-dihydro-1-[(4-methylphenyl)sulfonyl]-结构式

4(1H)-Quinolino...

间氯苯胺结构式

~%

4(1H)-Quinolinone,7-chloro-2,3-dihydro-1-[(4-methylphenyl)sulfonyl]-结构式

4(1H)-Quinolino...

Methyl N-(3-bromophenyl)-β-alaninate结构式

Methyl N-(3-bro...

~%

7-溴-2,3-二氢喹啉-4-酮结构式

7-溴-2,3-二氢喹啉-4-酮

3-溴苯胺结构式

~%

7-溴-2,3-二氢喹啉-4-酮结构式

7-溴-2,3-二氢喹啉-4-酮

2,3-二氢-1-[(4-甲基苯基)磺酰基]-4(1H)-喹啉酮结构式

2,3-二氢-1-[(4-甲基...

~83%

2,3-二氢-1H-喹啉-4-酮结构式

2,3-二氢-1H-喹啉-4-酮

2-氯苯胺结构式

~%

8-CHLORO-2,3-DIHYDROQUINOLIN-4(1H)-ONE结构式

8-CHLORO-2,3-DI...

N-(2-chlorophenyl)-β-alanine methyl ester结构式

N-(2-chlorophen...

~%

8-CHLORO-2,3-DIHYDROQUINOLIN-4(1H)-ONE结构式

8-CHLORO-2,3-DI...

3-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]propanoic acid结构式

3-[(3-chlorophe...

~%

7-氯-2,3-二氢喹啉-4(1H)-酮结构式

7-氯-2,3-二氢喹啉-4(1H)-酮

5-氯-2,3-二氢喹啉-4(1H)-酮结构式

5-氯-2,3-二氢喹啉-4(1H)-酮

methyl N-(3-chlorophenyl)-β-alaninate结构式

methyl N-(3-chl...

~%

5-氯-2,3-二氢喹啉-4(1H)-酮结构式

5-氯-2,3-二氢喹啉-4(1H)-酮

Synthesis of 2, 3-dihydro-4 (1H)-quinolones and the correspo...

[Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A. Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470]