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Combined Ugi??4CR/CuAAC Approach to Triazole??Based Neoglycolipids

K Pérez??Labrada, I Brouard, I Méndez…

文献索引:Perez-Labrada, Karell; Brouard, Ignacio; Mendez, Inmaculada; Rivera, Daniel G. Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4660 - 4670

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被引用次数: 7

摘要

Abstract New glycolipids that feature a carbohydrate/triazole/lipid hybrid architecture were readily produced by a combined multicomponent/click approach. The process comprises the use of the Ugi four-component reaction to construct double-lipidic scaffolds that have either alkyne or azide functionalities followed by conjugation to mono-and trisaccharides through a Cu I-catalyzed 1, 3-dipolar cycloaddition (click) process. The high chemical efficiency and ...