Bioorganic & medicinal chemistry letters

Triphenylmethylamides (TPMAs): Structure–activity relationship of compounds that induce apoptosis in melanoma cells

R Palchaudhuri, PJ Hergenrother

文献索引：Palchaudhuri, Rahul; Hergenrother, Paul J. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5888 - 5891

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被引用次数: 12

摘要

Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure– activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell ...