Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives

KL White, M Movassaghi

文献索引：Zhang, Zhi-Jing; Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui Organic Letters, 2014 , vol. 16, # 12 p. 3292 - 3295

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摘要

... ion 7. Given the natural occurrence of the characteristic aspidosperma skeleton with C21-oxygenation in both enantiomeric forms,(1, 16) we devised a ... amino acid 12 in 87% yield over two steps (Scheme 2). Slow addition of a solution of amino acid 12 and Hünig's ... (d) Ph 3 ...