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Analogs of steroid hormones. II. 6-(Cyclopentyl) derivatives of 2-naphthalenone

RE Juday, L Cubbage, J Mazur…

文献索引:Juday,R.E. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, p. 872 - 875

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被引用次数: 0

摘要

2-(2-Cyclopenten-1-yl)-3, 4-dihydro-6-methoxy-l (2H)-naph-thalenone (2).-Freshly distilled 3- bromor~-clopentene (16 g, 0.11 mole) wai added all at once to a mixture of 1 (15 g, 0.064 mole), NaH (1.76 g, 0.084 mole), and 70 ml of anhydrous DRIF at-10". Ai1 immediate temperature rise of about 20" was noted. After the reaction subsided, the mixture was stirred at room temperature for a few minutes and then treated with H20 and C6H6. The bemetie ...