Expert Opinion on Drug Metabolism and Toxicology 2009-09-01

Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.

Shilpi Pradhan, Kumar Abhishek, Francis Mah

文献索引：Expert Opin. Drug Metab. Toxicol. 5(9) , 1135-40, (2009)

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摘要

Epinastine is a topical ophthalmic antihistamine and a mast cell stabilizer indicated for treatment of symptoms associated with allergic conjunctivitis.The objective of this review is to provide a comprehensive overview of the pharmacology, clinical efficacy, tolerability and safety of epinastine 0.05% ophthalmic solution.Medline literature review from 1950 to 2008.Epinastine 0.05% ophthalmic solution was found to be a safe and effective medication for the relief of symptoms of allergic conjunctivitis. Epinastine demonstrates very low CNS and cardiac toxicity.