Aldehyde dehydrogenase inhibitors: α, β-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for …
…, MO Joly-Pharaboz, J Goré, J André, U Reichert
文献索引：Quash, Gerard; Fournet, Guy; Courvoisier, Charlotte; Martinez, Rosa M.; Chantepie, Jacqueline; Paret, Marie Julie; Pharaboz, Julie; Joly-Pharaboz, Marie Odile; Gore, Jacques; Andre, Jean; Reichert, Uwe European Journal of Medicinal Chemistry, 2008 , vol. 43, # 5 p. 906 - 916
The pharmacomodulation of the N atom of α, β-acetylenic aminothiolesters or the replacement of the thiolester moiety by more electrophilic groups did not permit any clear rationale to be established for improving the selective growth-inhibitory activity of this family of compounds over that of the previously synthesized α, β-acetylenic aminothiolesters DIMATE and MATE [G. Quash, G. Fournet, J. Chantepie, J. Goré, C. Ardiet, D. Ardail, Y. ...
