Tetrahedron Letters

Efficient assembly of α-aryl and α-vinyl nitriles via iron-catalyzed ether bond activation

X Fan, K Guo, YH Guan, LA Fu, XM Cui, H Lv, HB Zhu

文献索引：Fan, Xiaohui; Guo, Kun; Guan, Yong-Hong; Fu, Lin-An; Cui, Xiao-Meng; Lv, Hao; Zhu, Hong-Bo Tetrahedron Letters, 2014 , vol. 55, # 5 p. 1068 - 1071

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被引用次数: 4

摘要

A novel and practical method for the synthesis of diverse α-aryl and α-vinyl nitriles was developed via an iron-catalyzed sp 3 C–O ether bond cleavage with C–C bond formation in the reaction of π-activated ethers with TMSCN. ... Direct cyanation of π-activated ethers to synthesis of α-aryl and α-vinyl nitriles via iron-catalyzed sp 3 C–O ether bond cleavage was developed. ... Selected examples of biologically active α-aryl nitriles. Selected examples of biologically ...