Chemical & Pharmaceutical Bulletin 2014-01-01

Improved synthetic route to methyl 1-fluoroindan-1-carboxylate (FICA Me ester) and 4-methyl derivatives.

Jyunichi Koyanagi, Tomoyo Kamei, Miyuki Ishizaki, Hiroshi Nakamura, Tamiko Takahashi

文献索引：Chem. Pharm. Bull. 62(8) , 816-9, (2014)

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摘要

An improved synthetic route has been developed for the preparation of methyl 1-fluoroindan-1-carboxylate (FICA Me ester) from 1-indanone. Methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester) was also prepared following the same procedure.