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Synthesis and anticonvulsant activity of some ω-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives

Z Soyer, FS Kılıç, K Erol, V Pabuçcuoğlu

文献索引:Soyer, Zeynep; Kilic, Fatma Sultan; Erol, Kevser; Pabuccuoglu, Varol Farmaco, 2004 , vol. 59, # 8 p. 595 - 600

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被引用次数: 43

摘要

In this study, eight new ω-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives having 2, 6-dimethyl, 2, 6-dichloro, 2-chloro-6-methyl and 2-isopropyl substitutions on N-phenyl ring were synthesized to evaluate anticonvulsant activity against maximal electroshock test. The most active compounds in the series were the derivatives bearing 2-isopropyl and 2, 6-dimethyl substituents on N-phenyl ring.