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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Electrophilic aromatic substitution with N-methoxy-N-acylnitrenium ions generated from N-chloro-N-methoxy amides: syntheses of nitrogen heterocyclic compounds …

M Kawase, T Kitamura, Y Kikugawa

文献索引：Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403

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被引用次数: 117

摘要

N-Methoxy-N-acylnitrenium ions (11), generated by treatment of N-chloro-N-methoxyamides with silver carbonate in trifluoroacetic acid, react with arenes to give N-aryl-N- methoxyamides in good yields. In the case of the intramolecular cyclization of N-chloro-N- methoxy-2-phenylacetamides, the mode of cyclization is highly dependent on the nature of ortho or para substituent groups. Nitrenium ions I1 can primarily attack three positions (C- ...

1,5,6-trimethoxyindolin-2-one结构式

1,5,6-trimethox...

~90%

5,6-二甲氧基吲哚啉-2-酮结构式

5,6-二甲氧基吲哚啉-2-酮

3,4-二甲氧基苯乙酸结构式

3,4-二甲氧基苯乙酸

~%

5,6-二甲氧基吲哚啉-2-酮结构式

5,6-二甲氧基吲哚啉-2-酮

2-(3,4-dimethoxyphenyl)-N-methoxyacetamide结构式

2-(3,4-dimethox...

~%

5,6-二甲氧基吲哚啉-2-酮结构式

5,6-二甲氧基吲哚啉-2-酮

甲氧胺盐酸盐结构式

甲氧胺盐酸盐

3-苯丙酰氯结构式

~92%

N-methoxy-3-phenylpropanamide结构式

N-methoxy-3-phe...

1-methoxy-6-methylindolin-2-one结构式

1-methoxy-6-met...

~88%

6-甲基吲哚酮结构式

6-甲基吲哚酮

N-chloro-N-methoxy-2-(2-nitrophenyl)acetamide结构式

N-chloro-N-meth...

~54%

2-硝基苯乙酸结构式

2-硝基苯乙酸

1-methoxy-4-nitroindolin-2-one结构式

1-methoxy-4-nit...

Benzeneacetyl chloride,2-nitro-结构式

Benzeneacetyl c...

~%

2-硝基苯乙酸结构式

2-硝基苯乙酸

N-methoxy-2-(2-nitrophenyl)acetamide结构式

N-methoxy-2-(2-...

~%

2-硝基苯乙酸结构式

2-硝基苯乙酸

N-甲氧基苯甲酰胺结构式

N-甲氧基苯甲酰胺

~90%

N-chloro-N-methoxybenzamide结构式

N-chloro-N-meth...

未登录结构式

~96%

6-甲氧基吲哚啉-2-酮结构式

6-甲氧基吲哚啉-2-酮

甲氧胺盐酸盐结构式

甲氧胺盐酸盐

苯乙酰氯结构式

~95%

N-methoxy-2-phenylacetamide结构式

N-methoxy-2-phe...

1,5-dimethoxyindolin-2-one结构式

1,5-dimethoxyin...

~78%

5-甲氧基吲哚酮结构式

5-甲氧基吲哚酮

1-methoxy-4-methylindolin-2-one结构式

1-methoxy-4-met...

~94%

4-甲基吲哚酮结构式

4-甲基吲哚酮

1,3-dihydro-1-methoxy-2H-benz[c]indol-2-one结构式

1,3-dihydro-1-m...

~85%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

1-萘基乙酰氯结构式

1-萘基乙酰氯

~%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

2-(2-萘基)乙酰氯结构式

2-(2-萘基)乙酰氯

~%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

N-methoxy-2-(1-naphthyl)acetamide结构式

N-methoxy-2-(1-...

~%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

N-chloro-N-methoxy-2-(1-naphthyl)acetamide结构式

N-chloro-N-meth...

~%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

N-chloro-N-methoxy-2-(2-naphthyl)acetamide结构式

N-chloro-N-meth...

~%

1,3-dihydrobenzo[e]indol-2-one结构式

1,3-dihydrobenz...

4-chloro-1-methoxyindolin-2-one结构式

4-chloro-1-meth...

~40%

4-氯吲哚结构式

2-(2-bromophenyl)-N-methoxyacetamide结构式

2-(2-bromopheny...

~94%

2-(2-bromophenyl)-N-chloro-N-methoxyacetamide结构式

2-(2-bromopheny...

2-溴苯乙酰氯结构式

2-溴苯乙酰氯

~%

2-(2-bromophenyl)-N-chloro-N-methoxyacetamide结构式

2-(2-bromopheny...