Bioorganic & Medicinal Chemistry 2010-07-15

Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).

John Yang, Gwendolyn A Marriner, Xinyu Wang, Phillip D Bowman, Sean M Kerwin, Salomon Stavchansky

文献索引：Bioorg. Med. Chem. 18(14) , 5032-8, (2010)

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摘要

A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA.Copyright (c) 2010 Elsevier Ltd. All rights reserved.