Novel and Improved Process for the Preparation of Citalopram

MP Reddy, B Rao, V Usharani…

文献索引：Reddy, M. Pulla; Bhujanga Rao; Usharani; Dubey Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1829 - 1832

全文：HTML全文

被引用次数: 1

摘要

Abstract A novel process for the preparation of citalopram (1) has been described. The key intermediate 1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile (2) of citalopram is prepared using novel intermediates. The process involves simple acylation, hydrolysis and reduction, which can be easily adapted to commercial scale.