Journal of Combinatorial Chemistry 2007-01-01

Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides.

Ahmed Kamal, V Devaiah, K Laxma Reddy, Rajendar, Rajesh V C R N C Shetti, N Shankaraiah

文献索引：J. Comb. Chem. 9(2) , 267-74, (2007)

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摘要

A versatile method for the solid-phase synthesis of imidazo[1,2-a]pyridine-based derivatives, imidazo[1,2-a]pyridine-8-carboxamides, has been developed. They were obtained by treatment of the amino group of the polymer-bound 2-aminonicotinate with different alpha-haloketones, followed by halogenation at the 3-position of the polymer-bound imidazo[1,2-a]pyridine. The derived polymer-bound imidazo[1,2-a]pyridines 5, 6, and 7 were finally cleaved from the solid-support with an excess of primary or secondary amines. The final crude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE).