Tetrahedron

Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

IN Redwan, T Ljungdahl, M Grøtli

文献索引：Redwan, Itedale Namro; Ljungdahl, Thomas; Grotli, Morten Tetrahedron, 2012 , vol. 68, # 5 p. 1507 - 1514

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被引用次数: 4

摘要

Aminoacyl-tRNA synthetases (aaRSs) constitute a family of enzymes that transfer amino acids to their corresponding tRNA molecules to form aminoacyl-tRNAs and have been validated as potential drug targets. Sulfamoyloxy-linked aminoacyl-AMP analogues are potent inhibitors of aaRSs. In this article, we report the synthesis of several new sulfamoyl analogues of aa-AMP that up to now have been difficult or even impossible to prepare ...