Organic Letters 2003-04-03

Fluorous synthesis of disubstituted pyrimidines.

Wei Zhang

文献索引：Org. Lett. 5(7) , 1011-3, (2003)

全文：HTML全文

摘要

[reaction: see text] The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines or thiols. The fluorous chain serves as a phase tag for intermediate and product purification over FluoroFlash SPE cartridges.