4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase

M Boulouard, P Schumann-Bard, S Butt-Gueulle…

文献索引：Boulouard, Michel; Schumann-Bard, Pascale; Butt-Gueulle, Sabrina; Lohou, Elodie; Stiebing, Silvia; Collot, Valerie; Rault, Sylvain Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3177 - 3180

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被引用次数: 39

摘要

A series of halo-1-H-indazoles has been synthesized and evaluated for its inhibitory activity on neuronal nitric oxide synthase. Introduction of bromine at the C4 position of the indazole ring system provided a compound almost as potent as the reference compound, that is, 7- nitroindazole (7-NI). The importance of position 4 is further demonstrated by the synthesis and pharmacological evaluation of the 4-nitroindazole which was also a potent inhibitor of ...