Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

ER Wood, L Kuyper, KG Petrov, RN Hunter…

文献索引：Wood, Edgar R.; Kuyper, Lee; Petrov, Kimberly G.; Hunter III, Robert N.; Harris, Philip A.; Lackey, Karen Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 953 - 957

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被引用次数: 85

摘要

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4- hydroxy-5-(2′-methoxyphenyl)-benzylidene)-5-bromo-1, 3-dihydro-pyrrolo [2, 3-b] pyridin-2- one, 3-[(1-methyl-1H-indol-3-yl) methylene]-1, 3-dihydro-2H-pyrrolo [3, 2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.