Journal of Medicinal Chemistry

The preparation and biological activity of some N, N'-bis (haloacyl)-polymethylenediamines

AR Surrey, JR Mayer

文献索引：Surrey,A.R.; Mayer,J.R. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 419 - 425

全文：HTML全文

被引用次数: 16

摘要

We have reported1 that several symmetrical NJ'-dialkyl-N, N'-bia (dichloroacety1)-1, kxylylenediamines were found to possess unusually high antiamoebic properties both in vitro and in vivo and that a select few also showed antispermatogenic activity in rats and other species. This most intriguing combination of activities has led to additional investigations in several directions. Primarily, we have been searching for more potent ...