Synthesis and cytotoxic effect of 1, 3-dihydroxy-9, 10-anthraquinone derivatives

BL Wei, SH Wu, MI Chung, SJ Won, CN Lin

文献索引：Wei, Bai-Luh; Wu, Szu-Huei; Chung, Mei-Ing; Won, Shen-Jeu; Lin, Chun-Nan European Journal of Medicinal Chemistry, 2000 , vol. 35, # 12 p. 1089 - 1098

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被引用次数: 28

摘要

1, 3-Dihydroxy-9, 10-anthraquinone (4) was reacted with epichlorohydrin or 1, ω-dibromo- alkane to yield 1-hydroxy-3-(2, 3-epoxypropoxy)-9, 10-anthraquinone (5) and 1-hydroxy-3-(3- chloro-2-hydroxypropoxy)-9, 10-anthraquinone (6) or 1-hydroxy-3-(ω-bromoalkoxy)-9, 10- anthraquinone. Ring-opening of the epoxide (5) or 1-hydroxy-3-(ω-bromoalkoxy)-9, 10- anthraquinones with appropriate amines, afforded various 1-hydroxy-3-(3-alkylamino-2- ...