Bioorganic & Medicinal Chemistry Letters 1998-02-17

Synthesis of Dolastatin 15 mimetic peptoids.

J Schmitt, M Bernd, B Kutscher, H Kessler

文献索引：Bioorg. Med. Chem. Lett. 8(4) , 385-8, (1998)

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摘要

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.