Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS). Synthesis of a novel series of (3- …

…, Z Terashita, Y Shibouta, K Nishikawa

文献索引：Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Shibouta, Yumiko; Nishikawa, Kohei Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 267 - 276

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被引用次数: 53

摘要

A novel series of (3-pyridylmethy1) benzoquinone derivatives was molecular designed and synthesized for the dual purpose of inhibiting thromboxane Az and leukotriene biosynthesis enzymes and scavenging active oxygen species (AOS). They were evaluated for inhibition of TXAz synthase, inhibition of 5-lipoxygenase, and for their scavenging activity of AOS using the thiobarbituric acid method. 2, 3, 5-Trimethyl-6-(3-pyridylmethyl)-1, 4-~ ...