Helvetica Chimica Acta

Synthesis and Antimalarial??Activity Evaluation of Tetraoxane Triazine Hybrids and Spiro [piperidine??4, 3′??tetraoxanes]

N Kumar, SI Khan, DS Rawat

文献索引：Kumar, Nitin; Khan, Shabana I.; Rawat, Diwan S. Helvetica Chimica Acta, 2012 , vol. 95, # 7 p. 1181 - 1197

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被引用次数: 14

摘要

Abstract A series of tetraoxane [BOND] triazine hybrids and spiro [piperidine-4, 3′- tetraoxanes] have been synthesized, and all the compounds were screened for in vitro antimalarial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Most of the spiro [piperidine-4, 3′-tetraoxanes] exhibited moderate to good antimalarial activities, and two compounds have shown good ...