Aza-Diels–Alder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

…, Z ALJaroudi, BD Ellis, TS Cameron

文献索引：Jha, Amitabh; Chou, Ting-Yi; ALJaroudi, Zainab; Ellis, Bobby D.; Cameron, T. Stanley Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 848 - 857

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被引用次数: 5

摘要

Abstract The synthesis of 5-substituted 6, 6a-dihydroisoindolo [2, 1-a] quinolin-11 (5H)-ones via [4+ 2] imino-Diels–Alder cyclization from N-aryl-3-hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2- substituted-aryl)-3-hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl) ...