Inorganic Chemistry 2011-11-07

Luminescent Ir(III) complex exclusively made of polypyridine ligands capable of intercalating into calf-thymus DNA.

Sebastiano Campagna, Marco Cavazzini, Matteo Cusumano, Maria Letizia Di Pietro, Antonino Giannetto, Fausto Puntoriero, Silvio Quici

文献索引：Inorg. Chem. 50 , 10667-10672, (2011)

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摘要

Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA-dT)(2)] and strongly quenched in the presence of [poly(dG-dC)(2)]. By comparing the emission decays in DNA and in synthetic polynucleotides, it is proposed that the emission quenching of the title compound by guanine residues in DNA is no longer effective over a distance of four dA-dT base pairs.© 2011 American Chemical Society