Synthesis of isoquinolines. VI. N-alkyl-1, 2, 4-tetrahydroisoquinolines

JM Bobbitt, DN Roy, A Marchand…

文献索引：Bobbitt,J.M. et al. Journal of Organic Chemistry, 1967 , vol. 32, p. 2225 - 2227

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被引用次数: 44

摘要

Secondly, a method has been devised for preparing The droisoquinolines from substituted benzaldehydes in high over-all yields. corypalline and hydrohydrastinine, have been prepared. N-substituted 1, 2J3J4-tetrahydroisoquinolines where the alkyl group is varied from methyl to t-butyl. method uses glycidol followed by periodate oxidation to produce carbons 3 and 4 of the isoquinoline.