Tetrahedron letters

Diastereoselective allylations and crotylations under phase-transfer conditions using trifluoroborate salts: an application to the total synthesis of (−)-tetrahydrolipstatin

AN Thadani, RA Batey

文献索引：Thadani, Avinash N.; Batey, Robert A. Tetrahedron Letters, 2003 , vol. 44, # 44 p. 8051 - 8055

全文：HTML全文

被引用次数: 74

摘要

A mild protocol for diastereoselective allylations and crotylations of α-and β-silyloxy substituted aldehydes utilizing potassium allyl/crotyltrifluoroborates is described. The reactions proceed to completion within 30 min at room temperature in biphasic or aqueous media in the presence of a phase transfer catalyst. The resulting homoallylic alcohols are obtained in high yields and moderate to excellent diastereoselectivities. The method was ...