Microwave-assisted Piloty-Robinson synthesis of 3, 4-disubstituted pyrroles

BC Milgram, K Eskildsen, SM Richter…

文献索引：Milgram, Benjamin C.; Eskildsen, Katrine; Richter, Steven M.; Scheidt, W. Robert; Scheidt, Karl A. Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3941 - 3944

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被引用次数: 62

摘要

The synthesis of N-acyl 3, 4-disubstituted pyrroles can be accomplished directly from hydrazine and an aldehyde via a Piloty-Robinson pyrrole synthesis. The use of microwave radiation for the cyclization and pyrrole formation greatly reduces the time necessary for this process and facilitates moderate to good yields from hydrazine for the corresponding 3, 4- disubstituted products (5-12). By simple hydrolysis, the free NH pyrroles can be accessed ...