Synthesis of 2??Arylbenzoxazoles by Copper??Catalyzed Intramolecular Oxidative C O Coupling of Benzanilides

S Ueda, H Nagasawa

文献索引：Ueda, Satoshi; Nagasawa, Hideko Angewandte Chemie - International Edition, 2008 , vol. 47, # 34 p. 6411 - 6413

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被引用次数: 255

摘要

The benzoxazole moiety is an important structural motif in many biologically active natural products and pharmaceutical compounds.[1] Development of efficient methods to construct functionalized benzoxazole scaffolds is thus highly relevant for drug discovery. Traditional methods for the preparation of the benzoxazole framework include condensation reactions of 2-aminophenols with carboxylic acids in the presence of acid or the reaction of 2- ...