Organic Letters 2006-12-07

Highly active in situ catalysts for anti-Markovnikov hydration of terminal alkynes.

Aurélie Labonne, Thomas Kribber, Lukas Hintermann

文献索引：Org. Lett. 8 , 5853, (2006)

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摘要

The anti-Markovnikov hydration of terminal alkynes to give aldehydes is catalyzed by complexes derived in situ from air-stable [CpRu(eta6-naphthalene)]PF6 (C) and 6-aryl-2-diphenylphosphinopyridines (L). Ligands L are readily available from a modular synthesis. Increasing the size of the ligand C-6 aryl group in the order R = Ph < mesityl < 2,4,6-triisopropylphenyl < (2,4,6-triphenyl)phenyl gave hydration catalysts of highest known activity. [reaction: see text]