Tetrahedron

A new approach to isoindoloisoquinolinones. A simple synthesis of nuevamine

A Moreau, A Couture, E Deniau, P Grandclaudon…

文献索引：Moreau, Anne; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre; Lebrun, Stephane Tetrahedron, 2004 , vol. 60, # 29 p. 6169 - 6176

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被引用次数: 50

摘要

A convenient and versatile short step synthesis of isoindoloisoquinolinones, illustrated by the total synthesis of the alkaloid nuevamine, is described. The tetracyclic lactam compounds were obtained by a tactical combination of the Parham procedure for the elaboration of the isoindolinone template and an aryne-mediated cyclization giving rise to the nitrogen containing six-membered heteroring unit.