Molecules 2011-01-01

A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives.

Khadidja Bourahla, Ludovic Paquin, Olivier Lozach, Laurent Meijer, François Carreaux, Jean Pierre Bazureau

文献索引：Molecules 16(9) , 7377-90, (2011)

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摘要

A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.