Archiv der Pharmazie (Weinheim) 2010-09-01

Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents.

Alireza Moradi, Latifeh Navidpour, Mohsen Amini, Hamid Sadeghian, Hooman Shadnia, Omidreza Firouzi, Ramin Miri, Seyed Esmaeil Sadat Ebrahimi, Mohammad Abdollahi, Mona Haddad Zahmatkesh, Abbas Shafiee

文献索引：Arch. Pharm. (Weinheim) 343(9) , 509-18, (2010)

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摘要

A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti-inflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.