A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y 12 receptor

P Bach, J Boström, K Brickmann, JJJ van Giezen…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 2877 - 2881

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 5 Ticagrelor was discovered via a medicinal chemistry program starting from adenosine triphosphate (ATP), the natural antagonist of the P2Y ... Additional criteria were in-house availability of the isocyanates as well as chemical feasibility. ...