Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy†

ÁL Orcajo-Rincón, S Ortega-Gutiérrez…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 4 p. 1096 - 1100

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被引用次数: 7

摘要

... Journal of Medicinal Chemistry. ... NMR chemical shift perturbation studies with the ligand 1k enabled the identification of its binding site in the SH2 domain of Grb2 and to confirm that this family of molecules reproduces the key interactions predicted by the computational models ...