A Novel Synthesis of 2-Arylpyrrolo [1, 2-a] pyrimid-7-ones and Their Structure–Activity Relationships as Potent GnRH Receptor Antagonists

YF Zhu, K Wilcoxen, J Saunders, Z Guo, Y Gao…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 3 p. 403 - 406

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被引用次数: 28

摘要

... Bioorganic & Medicinal Chemistry Letters. ... In the previous letter, 1 we discussed the initial SAR study of a novel series of 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-ones (1) as human gonadotropin-releasing hormone (hGnRH) receptor antagonists. ...