The use of formamidine protection for the derivatization of aminobenzoic acids

PE Zhichkin, LH Peterson, CM Beer…

文献索引：Zhichkin, Paul E.; Peterson, Lisa H.; Beer, Catherine M.; Rennells, W. Martin Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8954 - 8959

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被引用次数: 16

摘要

N, N-Dimethylformamidine and novel N, N-diisopropylformamidine protecting groups were used to carry out a one-pot conversion of aminobenzoic acids into the corresponding amides. General conditions for an in situ transformation of aminobenzoic acids and their heterocyclic analogues into the corresponding formamidine-protected acid chlorides were developed. These chlorides were used in reactions with amines, including poorly reactive ...