A series of 2-(2, 6-dihalophenyl)-3-(substituted pyrimidinyl)-1, 3-thiazolidin-4-ones were designed on the prediction of quantitative structure–activity relationship (QSAR) studies, synthesized, and evaluated as HIV-1 reverse transcriptase inhibitors. Our attempts in correlating the identified molecular surface features related properties for modeling the HIV- 1 RT inhibitory activity resulted in some statistically significant QSAR models with good ...
