Pyrrolopyridazine MEK inhibitors

…, CS Ricca, J Gullo-Brown, MA Poss, W Vaccaro…

文献索引：Chen, Zhong; Kim, Soong-Hoon; Barbosa, Stephanie A.; Huynh, Tram; Tortolani, David R.; Leavitt, Kenneth J.; Wei, Donna D.; Manne, Veeraswamy; Ricca, Carolyn S.; Gullo-Brown, Johnni; Poss, Michael A.; Vaccaro, Wayne; Salvati, Mark E. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 628 - 632

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被引用次数: 13

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6. ... The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal ...