Early amidation approach to 3-[(4-amido) pyrrol-2-yl]-2-indolinones

…, CC Ball, JL Havens, R Vaidyanathan

文献索引：Manley, Jerad M.; Kalman, Monica J.; Conway, Brian G.; Ball, Cynthia C.; Havens, Jeffrey L.; Vaidyanathan, Rajappa Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6447 - 6450

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被引用次数: 74

摘要

A new synthesis of 3-[(4-amido) pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.