Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors

DH Shi, W Huang, C Li, LT Wang, SF Wang

文献索引：Shi, Da-Hua; Huang, Wei; Li, Chao; Wang, Ling-Ting; Wang, Shi-Fan Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1064 - 1073

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被引用次数: 14

摘要

A series of aloe-emodin derivatives were designed, synthesized and evaluated as acetylcholinesterase inhibitors. Most of the new prepared compounds showed remarkable acetylcholinesterase inhibitory activities. Among them, the compound 1-((4, 5-dihydroxy-9, 10-dioxo-9, 10-dihydroanthracen-2-yl) methyl) pyridin-1-ium chloride (C3) which has a pyridinium substituent possessed the best inhibitory activity of acetylcholinesterase (IC50= ...