Abstract The synthesis of novel functionalized 3-amino-N-methylfuro [3, 2-b] pyridine-2- carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl) oxy] acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo [3, 2-b] pyridines.