Tetrahedron

Design and synthesis of MMP inhibitors using N-arylsulfonylaziridine hydroxamic acids as constrained scaffolds

S Hanessian, N Moitessier, LD Cantin

文献索引：Hanessian, Stephen; Moitessier, Nicolas; Cantin, Louis-David Tetrahedron, 2001 , vol. 57, # 32 p. 6885 - 6900

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被引用次数: 24

摘要

The synthesis of cis-and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio-and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies.