Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer's disease agents

…, Z Huang, H Liao, S Peng, J Lehmann, Y Zhang

文献索引：Chen, Yao; Sun, Jianfei; Huang, Zhangjian; Liao, Hong; Peng, Sixun; Lehmann, Jochen; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2462 - 2470

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被引用次数: 13

摘要

To search for multifunctional anti-Alzheimer's disease (AD) agents with good safety, the previously synthesized tacrine–flurbiprofen hybrids 1a and 1b were modified into tacrine– flurbiprofen–nitrate trihybrids 3a–h. These compounds displayed comparable or higher cholinesterase inhibitory activity relative to the bivalent hybrids. Compound 3a was the most potent, which released moderate NO, exerted blood vessel relaxative activity, and showed ...