Enaminones as building blocks in heterocyclic syntheses: Reinvestigating the product structures of enaminones with malononitrile. A novel route to 6- …
AA Alnajjar, MM Abdelkhalik, A Al-Enezi, MH Elnagdi
Abstract: The reported structures of reaction products of enaminones with malononitrile in ethanolic piperidine are revised. A novel route to 2, 3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2, 4-dienamides 8a-c with nitrous acid or with benzenediazonium chloride is reported. Compounds 8a-c are converted to 1, 2-dihydropyridine-3-carboxylic acid and 1, 2-dihydropyridine-3-carbonitrile ...
