Tetrahedron

Superelectrophilic chemistry of amino-nitriles and related substrates

EK Raja, DA Klumpp

文献索引：Raja, Erum K.; Klumpp, Douglas A. Tetrahedron, 2011 , vol. 67, # 25 p. 4494 - 4497

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被引用次数: 8

摘要

Abstract The superacid-promoted Houben/Hoesch reactions of amino-nitriles and related compounds have been studied. The nitriles form dicationic electrophiles and react with benzene in fair to good yields (12–95%). The intermediate iminium ions may also be reduced to the benzylic amines by NaBH 4 or H 2.