New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations

S Hmuda, N Trišović, J Rogan, D Poleti, Ž Vitnik…

文献索引：Hmuda, Sleem; Trisovic, Nemanja; Rogan, Jelena; Poleti, Dejan; Vitnik, Zeljko; Vitnik, Vesna; Valentic, Natasa; Bozic, Biljana; Uscumlic, Gordana Monatshefte fur Chemie, 2014 , vol. 145, # 5 p. 821 - 833

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被引用次数: 9

摘要

Abstract Two new series of hydantoin derivatives, 3-(4-substituted benzyl)-5, 5-diphenyl-and 3-(4-substituted benzyl)-5-ethyl-5-phenylhydantoins, were synthesized and their antiproliferative activity was tested against human colon cancer HCT-116 and breast cancer MDA-MB-231 cell lines. The presence of different substituents on both hydantoin and benzyl moieties changed the antiproliferative activity of the investigated hydantoins, whereby ...