Streamlined synthesis of the Bippyphos family of ligands and cross-coupling applications

GJ Withbroe, RA Singer, JE Sieser

文献索引：Withbroe, Gregory J.; Singer, Robert A.; Sieser, Janice E. Organic Process Research and Development, 2008 , vol. 12, # 3 p. 480 - 489

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被引用次数: 65

摘要

We describe the efficient preparation of Bippyphos, 1. The key precursor to Bippyphos, 5, was prepared via a one-pot bromination of diketone 2 followed by alkylation with pyrazole and condensation with phenylhydrazine. Lithiation of 5 and trapping with di-tert- butylchlorophosphine afforded Bippyphos, 1. Using this approach we have prepared several derivatives of Bippyphos to probe the structure and activity relationships of this family of ...