Synthesis and cytostatic activities of new 6-substituted purinylcarbonucleosides derived from indan

…, X García-Mera, M Morales, JE Rodríguez-Borges…

文献索引：Fernandez, Franco; Garcia-Mera, Xerardo; Morales, Melvin; Rodriguez-Borges, Jose E.; De Clercq, Eric Synthesis, 2002 , # 8 p. 1084 - 1090

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被引用次数: 23

摘要

Abstract A new series of 6-substituted purinylcarbonucleosides derivatives of indan, 8a-g and 10a-d, was synthesized from (±)-cis-1, 3-indandimethanol acetate (5), which was prepared in three steps from benzonorbornadiene. 6-Chloropurine was introduced both by Mitsunobu reaction with 5 and by substitution of the mesylate 6. Suzuki-Miyaura reactions of the protected 6-chloropurine derivative 7 with substituted phenylboronic acids afforded 9a ...